Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles.

Oliver J Turner,John A Murphy,David J Hirst,Eric P A Talbot

CHEMISTRY-A EUROPEAN JOURNAL（2018）

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摘要

Hydrogen atom transfer-mediated intramolecular C-C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)(3), are described. This introduces a new strategic bond disconnection for ring-closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.

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关键词

cyclization,hydrogen transfer,iron(III),nitriles,radicals

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