Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.

João Paulo Bizarro Lopes,Luana Silva, Gabriela da Costa Franarin,Marco Antonio Ceschi,Diogo Seibert Lüdtke,Rafael Ferreira Dantas,Cristiane Martins Cardoso de Salles,Floriano Paes Silva-Jr,Mario Roberto Senger,Isabella Alvim Guedes,Laurent Emmanuel Dardenne

Bioorganic & Medicinal Chemistry（2018）

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摘要

•New hybrids tacrine-carbohydrate derivatives were synthesized.•Molecular docking studies were performed.•All compounds were found to be potent inhibitors of AChE and BuChE.•Most compounds do not violate the Lipinski's rules.

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关键词

Tacrine,Carbohydrate,Xylose,Ribose,Galactose,Cholinesterases,Molecular modeling,Alzheimer

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