When Small Molecules Are Like Real Estate: It's All about Location, Location, Location.
Cell Chemical Biology(2018)
摘要
In this issue of Cell Chemical Biology, Park et al. (2018) demonstrate that targeting apoptazole, an Hsp70 inhibitor, to mitochondria induces apoptosis by a distinct mechanism of action different from unmodified apoptazole, which accumulates in the lysosome. These results highlight the power of subcellular localization in small-molecule selectivity.
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