Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation.

Thomas Bärnthaler,Katharina Jandl,Heinz Sill,Barbara Uhl,Yannick Schreiber,Magdalena Grill,Dominique Thomas,Rudolf Schicho,Gunther Marsche,Saša Frank,Akos Heinemann,Rufina Schuligoi

The Journal of allergy and clinical immunology（2018）

引用 12|浏览30

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摘要

Imatinib increases PGE levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent.

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