Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974.

Hirotake Shiraiwa,Atsushi Narita,Mika Kamata-Sakurai,Takahiro Ishiguro,Yuji Sano,Naoka Hironiwa,Takashi Tsushima,Hiroaki Segawa,Toshiaki Tsunenari, Yosuke Ikeda,Yoko Kayukawa,Mizuho Noguchi,Tetsuya Wakabayashi,Akihisa Sakamoto,Hiroko Konishi,Taichi Kuramochi,Mika Endo,Kunihiro Hattori,Junichi Nezu,Tomoyuki Igawa

Methods（2019）

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摘要

•History and methods of bispecific antibody generation with a common light chain.•Actual engineering of common light chain and other properties for bispecific antibody.•T-cell redirecting biAb ERY974 shows strong anti-tumor effect in preclinical studies.

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关键词

Bispecific antibody engineering,Common light chain,T cell redirecting,ERY974

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