Cachexia does not induce loss of myonuclei or muscle fibers during xenografted prostate cancer in mice.

The data suggest that the cachexia induced by xenografted prostate tumors induces a pronounced atrophy not accompanied by a loss of myonuclei or a loss of muscle fibers. Thus, stem-cell related treatment might not be beneficial, and the quest for treatment options should rather focus on intervening with intracellular pathways regulating muscle fiber-size. This article is protected by copyright. All rights reserved.