Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-8.

Yumi Takiyama,Toshihiro Sera,Masanori Nakamura,Kanaki Ishizeki,Yasuaki Saijo,Tsuyoshi Yanagimachi,Manami Maeda,Ryoichi Bessho,Takao Takiyama,Hiroya Kitsunai,Hidemitsu Sakagami, Daisuke Fujishiro,Yukihiro Fujita,Yuichi Makino,Atsuko Abiko,Masato Hoshino,Kentaro Uesugi,Naoto Yagi,Tsuguhito Ota,Masakazu Haneda

EBioMedicine（2018）

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摘要

Based on our findings, SGLT2 inhibitors may alter glomerular distribution and size in addition to their glucose-lowering effects, presumably by affecting oxygen metabolism and humoral factors. FUND: Funding for this research was provided by The Japan Society for the Promotion of Science, the Japan Diabetes Foundation, and Asahikawa Medical University.

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关键词

micro-CT,SPring-8,SGLT,HbA1c,UAE,PAS,TR,Nglom,Vglom,SBP,FBS,Vkidney,Rglom/kidney,CV,EA,AA

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