PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues.

Pierre-Gilles Blanchard,Rafael J Moreira,Érique Castro,Alexandre Caron,Marie Côté,Maynara L Andrade,Tiago E Oliveira,Milene Ortiz-Silva,Albert S Peixoto,France Anne Dias,Yves Gélinas,Renata Guerra-Sá,Yves Deshaies,William T Festuccia

Metabolism（2018）

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摘要

•Adipocyte PPARγ is a major modulator of BCAA metabolism and homeostasis.•Pharmacological PPARγ activation increases adipocyte BCAA catabolism.•BAT has a stronger BCAA catabolic activity than subcutaneous fat.

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