Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.

•Kinetic interactions between human AChE, organophosphates and novel non-oximes were investigated.•The non-oxime 3 l, a potent reversible AChE inhibitor, protected AChE from irreversible inhibition by organophosphates.•3 l exhibited a several fold higher reactivating potency compared to ADOC.•3 l may be considered as a promising template for the development of more effective reactivators.