Clinical and in vitro studies of the correlation between MGMT and the effect of streptozocin in pancreatic NET.

Susumu Hijioka,Keiichiro Sakuma,Masahiro Aoki,Nobumasa Mizuno,Takamichi Kuwahara,Nozomi Okuno,Kazuo Hara,Yasushi Yatabe

Cancer chemotherapy and pharmacology（2019）

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摘要

We observed a relationship between MGMT status and streptozocin response in both patients and cell culture. Despite limited cases examined, high concordance of negative expression of MGMT and response to streptozocin treatment suggest that MGMT expression can be a potential biomarker for this treatment.

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关键词

MGMT,Streptozocin,Pancreatic neuroendocrine tumors,Methylation,BON1

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