Targeted next generation sequencing reveals high mutation frequency of CREBBP , BCL2 and KMT2D in high-grade B-cell lymphoma with MYC and BCL2 and /or BCL6 rearrangements.

Solène M Evrard,Sarah Péricart,David Grand,Nadia Amara,Frédéric Escudié,Julia Gilhodes,Pierre Bories,Alexandra Traverse-Glehen,Romain Dubois,Pierre Brousset,Marie Parrens,Camille Laurent

HAEMATOLOGICA（2019）

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摘要

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, representing approximately 30-40% of all cases.[1][1] The update of the 4th edition of the 2017 WHO classification provides new concepts in the classification of DLBCL.[1][1] Importantly, the category “B-cell

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关键词

Aggressive Non-Hodgkin's Lymphoma,CREBBP mutation,Cytogenetics and Molecular Genetics,Double Hit Lymphoma,Targeted Next Generation Sequencing

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