Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial

    David J Collier
    David J Collier
    [0]
    Attila Juhasz
    Attila Juhasz
    Enrico Agabiti-Rosei
    Enrico Agabiti-Rosei
    [0]
    Eric Lloyd
    Eric Lloyd
    [0]
    Michie Hisada
    Michie Hisada
    Lin Zhao
    Lin Zhao
    Stuart Kupfer
    Stuart Kupfer
    [0]
    Mark J Caulfield
    Mark J Caulfield
    [0]

    Journal of clinical hypertension (Greenwich, Conn.), 2018.

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    Keywords:
    Hypertension-generalantihypertensive therapyclinical management of high blood pressure (HBP)clinical trialscombination therapy

    Abstract:

    Patients with grade 2-3 essential hypertension and postplacebo mean clinic systolic blood pressure (SBP) 160-190 mm Hg and 24-hour SBP 140-175 mm Hg by ambulatory blood pressure monitoring (ABPM) received 40 mg azilsartan medoxomil (AZL-M) monotherapy for 4 weeks. "Nonresponders" were then randomized to 8 weeks of double-blind treatment w...More

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