Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice.

Cuihong Jia,Russell W Brown,Hannah M Malone,Katherine C Burgess,W Drew Gill,Matthew P Keasey,Theo Hagg

Psychoneuroendocrinology（2019）

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摘要

•CNTF plays a sex-specific role in depressive-like behavior.•CNTF is pro-depressive in female mice but anti-depressive in male mice.•The anti-depressant effect of progesterone is through inhibition of CNTF in the amygdala.

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关键词

Depression,Anxiety,Progesterone,Amygdala,Ovariectomy,Castration

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