Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification.

Madyson P Middleton,Scott A Armstrong,Kevin L Bicker

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•An iterative SAR was carried out on the antifungal peptoid AEC5.•Subtle modifications improved both antifungal potency and selectivity.•β-5 shows promise to contribute to the challenging field of antifungals.

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