Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression.

Ester Francija,Zorica Petrovic,Zeljka Brkic,Milos Mitic,Jelena Radulovic,Miroslav Adzic

Behavioural Brain Research（2019）

引用 23|浏览18

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摘要

•GluN2A KO mice displayed resiliance to depressive-like behaviour upon LPS.•GluN2A KO mice abolishes LPS induced inflammation.•LPS treated GluN2A KO mice showed elevated proBDNF in the PFC & hippocampus and increased NCAM in PFC.•GluN2A KO mice exhibited sustained PSA-NCAM levels in the PFC and hippocampus.•GluN2A KO potentiated synaptic stabilization through NCAM in the PFC upon LPS.

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关键词

GluN2A knockout mice,Lipopolysaccharide,Depressive-like behavior,Synaptosomes,Neuroplasticity,Glutamatergic neurotransmission

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