EFFECTS OF THE PESTICIDE CHLORPYRIFOS ON BREAST CANCER DISEASE. IMPLICATION OF EPIGENETIC MECHANISMS.

C Ventura, C D Zappia, M Lasagna,W Pavicic,S Richard,A D Bolzan,F Monczor,M Núñez,C Cocca

The Journal of Steroid Biochemistry and Molecular Biology（2019）

引用 38|浏览13

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摘要

•CPF is an organophosphate pesticide fully used for agricultural pest control.•CPF increases tumor incidence and reduces latency period in NMU-induced mammary tumors.•CPF decreases steroid hormone receptor expression in NMU-induced mammary tumors.•CPF alters HDAC1 mRNA expression in mammary gland of chronically exposed rats.

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关键词

ADI,ALAT,BChE,COBRA,CPF,DNMT,DTNB,ED,ERα,HDAC,LINE-1,LP,NMU,NOAEL,PCNA,PgR,TI

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