A holistic approach to unravelling chondroitin sulfation: Correlations between surface charge, structure and binding to growth factors.

Raúl Benito-Arenas,Ernesto Doncel-Pérez,Mar Fernández-Gutiérrez,Leoncio Garrido,Eduardo García-Junceda,Julia Revuelta,Agatha Bastida,Alfonso Fernández-Mayoralas

Carbohydrate Polymers（2018）

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摘要

•Chondroitin sulfate (CS) derivatives sulfation-dependently bind growth factors.•The disposition of the sulfates modulates the surface charge of the helical structure.•O-6 sulfation favours the arrangement of sulfates on the surface.•High-sulfated CS variants on the surface enhance the binding capacity.

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关键词

Glycosaminoglycan,Chondroitin sulfate,Structure-activity relationships,Protein interactions

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