Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

Jan Van den Bossche,Gerritje J W van der Windt

Cell Metabolism（2018）

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摘要

Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes.

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