Different aspects of platelet evaluation in dengue: Measurement of circulating mediators, ability to interact with the virus, the degree of activation and quantification of intraplatelet protein content

Tamiris Azamor da Costa Barros, Débora de Oliveira Batista, Amanda Torrentes de Carvalho,Nieli Rodrigues da Costa Faria, Débora Ferreira Barreto-Vieira,Fernanda Cunha Jácome,Ortrud Monika Barth,Rita Maria Ribeiro Nogueira, Patrícia Cristina da Costa Neves, Denise Cristina de Souza Matos,Elzinandes Leal de Azeredo,Paulo Vieira Damasco,Rivaldo Venâncio da Cunha,Luzia Maria de-Oliveira-Pinto

Virus Research（2019）

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摘要

•CD62P, NO and TBX2 ratio in platelet count may be predictors of dengue outcome.•Platelets undergo morphological activation with increase of CD62P in dengue.•Intraplatelet proteins content revealed differential profile based on the severity.•Activated platelets act on angiogenesis, inflammation, coagulation and extracellular matrix.

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关键词

Platelets,Dengue,Activation markers

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