Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies.

Christian Borgo,Jordi Vilardell,Valentina Bosello-Travain,Lorenzo A Pinna,Andrea Venerando,Mauro Salvi

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

引用 12|浏览20

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摘要

•HSP27 cellular level is regulated by protein kinase CK2.•HSP27 is not a CK2 direct substrate.•CK2 controls HSP27 protein level via SMURF2.•A combination of CK2 inhibition and thermotherapy for cancer treatment is proposed.

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关键词

Protein kinase CK2,HSP27, SMURF2,Thermotherapy,Cancer

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