Fetal lung transcriptome patterns in an ex vivo compression model of diaphragmatic hernia.

Zachary D Fox,Guihua Jiang,Kenneth K Y Ho, Kendal A Walker,Allen P Liu,Shaun M Kunisaki

Journal of Surgical Research（2018）

引用 8|浏览12

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摘要

Collectively, these pilot data in a model of CDH lung hypoplasia suggest a primary aberration in response to mechanical stress within the nitrofen lung, characterized by an upregulation of ACTA2 and a downregulation in SPFTC and POSTN. This ex vivo compression system may serve as a novel research platform to better understand the mechanobiology and complex regulation of matricellular dynamics during CDH fetal lung development.

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关键词

Pulmonary hypoplasia,Lung development,Congenital diaphragmatic hernia,Mechanical compression,Periostin

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