The inhibition of thymidine phosphorylase can reverse acquire 5FU resistance in gastric cancer cells.

Ryutaro Mori,Kazuhiro Yoshida,Manabu Futamura,Tomonari Suetsugu,Kaoru Shizu,Toshiyuki Tanahashi,Yoshihiro Tanaka, Nobuhisha Matsuhashi,Kazuya Yamaguchi

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association（2019）

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摘要

In MKN45/F2R cells, the reduction of FdUMP through the TP-TK pathway caused 5FU resistance, and the inhibition of TP reversed the resistance to 5FU, suggesting that the combination of 5FU and TPI is a promising cancer therapy.

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关键词

5FU,Drug resistance,Stomach neoplasms,Thymidine phosphorylase

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