PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Maikel L Colli,Jessica L E Hill,Laura Marroquí,Jessica Chaffey,Reinaldo S Dos Santos,Pia Leete,Alexandra Coomans de Brachène,Flavia M M Paula,Anne Op de Beeck,Angela Castela,Lorella Marselli,Lars Krogvold,Knut Dahl-Jorgensen,Piero Marchetti,Noel G Morgan,Sarah J Richardson,Décio L Eizirik

EBioMedicine（2018）

引用 137|浏览63

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摘要

These findings indicate that PDL1 is expressed in beta cells from people with T1D, possibly to attenuate the autoimmune assault, and that it is induced by both type I and II interferons via IRF1.

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关键词

Type 1 diabetes,PDL1,PDL-1,Pancreatic beta cells,Pancreatic islets,IRF1,Immune checkpoint inhibitor,CD274

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