Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury

    Junbo Zheng
    Junbo Zheng
    Yongbo Huang
    Yongbo Huang
    Diana Islam
    Diana Islam
    Xiao-Yan Wen
    Xiao-Yan Wen
    Manshu Li
    Manshu Li
    Julie Khang
    Julie Khang
    Bing Han
    Bing Han

    Respiratory research, Volume 19, Issue 1, 2018, Pages 190

    Cited by: 2|Bibtex|Views42|Links
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    Keywords:
    α-DefensinsNeutrophilP2Y6 purinergic receptorBacteria clearanceInflammationMore(1+)

    Abstract:

    HNP exerted dual effects by exhibiting antimicrobial activity in pneumonia alone condition while enhancing inflammatory responses in pneumonia followed by HP mechanical ventilation. Blocking P2Y can attenuate the inflammation without affecting the antibacterial property of HNP. The P2Y receptor may be a novel therapeutic target in attenua...More

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