NMR-based metabonomic approach reveals changes in the urinary and fecal metabolome caused by resveratrol.

•Effects of pure resveratrol on the urinary and fecal metabolome of normal female Wistar rats was studied by an NMR-based metabolomics approach.•Resveratrol (RSV) causes significant variations of endogenous metabolites during the first 12 h after its administration.•RSV modulates the composition and/or the function of the host gut microbiota.•RSV may be involved in the control of energy homeostasis and downregulation of some biomarkers of oxidative stress.•The effects of RSV are dose-dependent.