Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.

Dan Liu,Jia Xue,Yusi Liu,Hui Gu,Xiaowei Wei,Wei Ma,Wenting Luo,Ling Ma,Shanshan Jia,Naixuan Dong,Jieting Huang,Yanfu Wang,Zhengwei Yuan

NeuroToxicology（2018）

引用 15|浏览3

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摘要

•Oxidative stress is induced and NRF2 signaling is inhibited in atRA-induced NTDs.•NRF2 inhibition weakens cellular defenses against atRA-induced oxidative stress.•NRF2 signaling plays an important role in the occurrence of atRA-induced NTDs.•NRF2 activation should be considered for NTD prevention and treatment.

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关键词

Nrf2,Keap1,ARE,HO-1,NQO1,GSTs,TXNRD,GCLC,GCLM,GR,ROS,GSH,GSSG

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