Pulmonary Dysfunction Function and Poor Nutritional Status are Risk Factors for Remote Infections Following Surgery for Colorectal Cancer.
JOURNAL OF NIPPON MEDICAL SCHOOL(2018)
摘要
Objective: We evaluated the preoperative patient status including nutrition, immunity, and inflammation as a predictive factor of remote infection (RI) in colorectal cancer surgery. Subjects and Methods: A total of 351 patients who underwent colorectal cancer resection were retrospectively analyzed. Factors correlated with RI incidence were identified by logistic analysis and stepwise selection. Results: RI occurred in 27 patients, with an incidence of 7.7%. In univariate logistic analysis, a significantly high incidence of RI was associated with excessive blood loss (>423 mL), long duration of surgery (>279 minutes), ileus, pulmonary dysfunction, performance status (PS)>= 1, American Society of Anesthesiologists (ASA) classification>2, prognostic nutritional index (PNI)<= 40, and controlling nutritional status (CONUT)>= 2, modified Glasgow Prognostic Score (mGPS) (Score 2). In multivariate analysis, pulmonary dysfunction (odds ratio=2.83; 95% CI: 1.14-6.97; p=0.02) and PNI <= 40 (odds ratio=3.87; 95% CI: 1.45-10.31; p=0.006) were independent risk factors of RI incidence. Conclusion: RI is caused by poor nutrition, immune system dysfunction and pulmonary dysfunction.
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关键词
remote infection (RI),colorectal cancer surgery,pulmonary dysfunction,prognostic nutritional index (PNI),modified Glasgow Prognostic Score (mGPS)
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