A novel model of trauma-induced cerebellar injury and myelin loss in mouse organotypic cerebellar slice cultures using live imaging.

Gemma Llufriu-Dabén,Delphine Meffre,Charbel Massaad,Mehrnaz Jafarian-Tehrani

Journal of Neuroscience Methods（2019）

引用 6|浏览21

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摘要

•A novel weight-drop model of TBI in mouse cerebellar slice cultures.•Live imaging of trauma-induced cell death and myelin loss ex vivo.•Etazolate protective effects on cerebellar injury and myelin loss ex vivo.•Suitable model to test active compounds against cerebellar injury.

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关键词

Traumatic brain injury,Focal lesion,Demyelination,Cerebellum,Neuroprotection,Myelin repair

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