Aortic valve calcification and risk of stroke: A systematic review and meta-analysis.

•The relationship between AVC and stroke was investigated by a meta-analysis.•Significant correlation between AVC and stroke was detected with low heterogeneity (RR, 1.20; 95% CI, 1.02–1.40, P = 0.02).•Subgroup analysis indicated no significant results in all subgroups except one group.•The relationship between AVC and risk of stroke couldn’t be determined based on current available studies.