Icariin and mesenchymal stem cells synergistically promote angiogenesis and neurogenesis after cerebral ischemia via PI3K and ERK1/2 pathways.

Dandan Liu,Yilu Ye,Linhao Xu, Wenxia Yuan,Qi Zhang

Biomedicine & Pharmacotherapy（2018）

引用 46|浏览4

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摘要

•ICA and MSCs increased VEGF and BDNF expression to a maximum.•ICA and MSCs functioned through PI3K/Akt and ERK1/2 pathways.•ICA and MSCs notably promoted angiogenesis and neurogenesis in vivo.•ICA and MSCs had synergistic effect on cerebral ischemia treatment.

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关键词

Icariin,Mesenchymal stem cell,Stroke,Cerebral ischemia,BDNF,VEGF,ERK1/2,PI3K,Angiogenesis,Neurogenesis

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