Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression.

European Neuropsychopharmacology（2018）

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摘要

•We investigated the role of let-7d and D3R in anxiety and depression.•let-7d overexpression was anxiolytic in the OF and EPM tests.•let-7d overexpression was anti-depressant in the TST and FST.•D3R mRNA negatively correlates with let-7d expression.•D3R overexpression was anxiogenic and pro-depressant.

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关键词

Anxiety,Depression,Dopamine D3 receptor,Lentiviral vector,let-7d,microRNAs

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