PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism.

Qihong Yu,Wei Li,Dawei Xie,Xichuan Zheng,Tong Huang,Ping Xue,Bing Guo,Yang Gao,Chen Zhang,Ping Sun,Min Li,Guoliang Wang,Xiang Cheng,Qichang Zheng,Zifang Song

EBioMedicine（2018）

引用 11|浏览20

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摘要

These results suggest that PI3Kγ plays a critical role in VSMC phenotypic modulation via a SOX9-dependent mechanism. Therefore, PI3Kγ in VSMCs may represent a promising therapeutic target for the treatment of TA. FUND: National Natural Science Foundation of China.

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关键词

PI3Kγ,Vascular smooth muscle cells,Transplant arteriosclerosis,SOX9,Phenotypic modulation

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