Synergistic and bactericidal activities of mecillinam, amoxicillin and clavulanic acid combinations against ESBL-producing Escherichia coli in 24-h time-kill experiments.

Kari-Pekka Skarp,Ayda Shams,Hanna Montelin,Pernilla Lagerbäck,Thomas Tängdén

International Journal of Antimicrobial Agents（2019）

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摘要

•Clinical efficacy of mecillinam is uncertain against ESBL-producing Escherichia coli.•Combination of mecillinam, amoxicillin and clavulanic acid has synergistic activity.•The three-drug combination could be clinically useful for urinary tract infections.

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关键词

Amdinocillin,Mecillinam,Synergy,Extended-spectrum β-lactamase,ESBL,Urinary tract infection

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