Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with advanced solid tumour

    Jianrong Zhang
    Jianrong Zhang
    Yiyin Zhang
    Yiyin Zhang
    Shiyan Tang
    Shiyan Tang
    Qihua He
    Qihua He
    Lindsey Tristine Hamblin
    Lindsey Tristine Hamblin
    Zhiheng Xu
    Zhiheng Xu
    Jieyu Wu
    Jieyu Wu
    Yaoqi Chen
    Yaoqi Chen
    Hengrui Liang
    Hengrui Liang
    Difei Chen
    Difei Chen

    BMJ open, Volume 8, Issue 9, 2018.

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    Keywords:
    blind independent central reviewlocal assessmentoncological randomized control trials

    Abstract:

    No systematic bias could be found between local and central assessments in phase III RCTs on solid tumours. However, statistically inconsistent inferences could be made in many trials between both assessments.

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