Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.
Molecular Metabolism(2018)
摘要
•Characterisation of the human hypothalamic peptidome in vitro and in vivo.•hPSC-derived POMC neurons correctly process POMC into peptides important for regulating feeding and energy balance, including β-MSH.•β-MSH and desacetyl α-MSH are produced in excess of acetylated α-MSH in primary and hPSC-derived human hypothalamic cells.•Leptin significantly increases the production of human POMC-derived peptides.
更多查看译文
关键词
POMC,Human pluripotent stem cell,Obesity,MSH,Leptin,Neuropeptide
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络