Effect of fingolimod action on the release of monocyte-derived microvesicles in multiple sclerosis patients.

Antonella Amoruso,Maria Blonda,Giulia D'Arrigo,Roberta Grasso,Valeria Di Francescantonio,Claudia Verderio,Carlo Avolio

Journal of Neuroimmunology（2018）

引用 8|浏览9

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摘要

Recently, microvesicles (MVs) were considered as important mediators of intercellular communication, especially in pathological conditions as Multiple Sclerosis (MS). In myeloid cells, MV shedding is induced by the receptor P2X7 with the involvement of acid sphingomyelinase (A-SMase) and release of the IL-1β.

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关键词

Multiple sclerosis,Microvesicles,Fingolimod,P2X7 receptor,Acid sphingomyelinase,IL-1β

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