Nrf2 deletion results in imparied performance in memory tasks and hyperactivity in mature and aged mice.

Mark M Gergues,Anastasiya Moiseyenko,Syed Z Saad, Ah-Ng Kong,George C Wagner

Brain Research（2018）

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摘要

•Deletion of NRF2 resulted in enhanced motor performance.•Deletion of NRF2 resulted in impaired cognitive performance with age.•Deletion of NRF2 resulted in subtle changes in brain monoamines.

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关键词

Oxidative stress,Nrf2,Active avoidance,Hyperactivity

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