Antiretroviral concentrations in hair strongly predict virologic response in a large HIV treatment-naive clinical trial.

Monica Gandhi,Igho Ofokotun,Peter Bacchetti,Chengshi Jin,Heather J Ribaudo,David W Haas,Anandi N Sheth,Howard Horng,Nhi Phung,Karen Kuncze,Hideaki Okochi,Raphael J Landovitz,Jeffrey Lennox,Judith S Currier

CLINICAL INFECTIOUS DISEASES（2019）

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摘要

Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals but have never been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naive trial (AIDS Clinical Trials Group protocol A5257).

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关键词

HIV,A5257 study,AIDS Clinical Trials Group (ACTG),hair concentrations,non-NNRTI regimens

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