Hybrids of arenobufagin and benzoisoselenazol reducing the cardiotoxicity of arenobufagin.

Wen Hou,Zhi-Xing Huang,Hong-Gui Xu,Jing Lin,Dong-Mei Zhang,Qun-Long Peng,Hui Lin,Yi-Qun Chang,Long-Hai Wang,Zhe Yao,Ping-Hua Sun,Wei-Min Chen

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

A series of novel benzoisoselenazol-containing arenobufagin hybrids were designed, synthesized and their in vitro cytotoxicity for cancer cell lines and AC16 cell line, as well as their ROS scavenge activities were evaluated. Among them, 6d and 6f exhibited ROS scavenge activities and less cardiotoxcity.

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关键词

Arenobufagin,Benzoisoselenazol,Antitumor,Reactive oxygen species,Hybridization

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