X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

Pierre Montay-Gruel,Audrey Bouchet,Maud Jaccard,David Patin,Raphael Serduc, Warren Aim,Kristoffer Petersson,Benoit Petit,Claude Bailat,Jean Bourhis,Elke Bräuer-Krisch,Marie-Catherine Vozenin

Radiotherapy and Oncology（2018）

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摘要

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.

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关键词

Ultra-high dose-rate X-ray radiation,Synchrotron radiation,Cognitive impairment,Radiation-induced brain injury

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