Gold nanoparticles-enhanced ion-transmission mass spectrometry for highly sensitive detection of chemical warfare agent simulants.

Gold nanoparticles (AuNPs)-embedded paper was coupled with ion-transmission mass spectrometry (MS) to enable the highly sensitive detection of chemical warfare agent (CWA) simulants in solutions. With the assistance of a low-temperature plasma (LTP) probe, we found that AuNPs were capable to enhance the ionization efficiencies of target analytes, with MS signal intensities surprisingly undergone an 800-fold increase under optimized conditions. The interaction between AuNPs and the radiofrequency electromagnetic field was believed to promote the desorption/ionization process, resulting in the unusual signal enhancement phenomenon. Based on this finding, we established a method for the rapid analysis of two simulants of nerve agents, dimethyl methylphosphonate (DMMP) and diisopropyl methylphosphonate (DIMP), with a dynamic range from 0.5 ng/mL to 100 ng/mL and detection limits of 0.1 ng/mL and 0.3 ng/mL, respectively. As sample pretreatments have been eliminated, the developed strategy is particularly promising for the on-site detection of CWAs considering its simple and rapid analytical workflow.