The role of heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by Visfatin.

Haifeng Chen,Nan Lu,Changsheng Xu,Meifan Zheng

Microvascular Research（2019）

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摘要

•Visfatin induced HSP27 phosphorylation and prompted cell proliferation.•Visfatin exerted a protective effect against high-glucose induced apoptosis in HUVECs through HSP27 phosphorylation.•PI3K/Akt and ERK1/2 are important signaling pathways that contribute to HSP27 phosphorylation.

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关键词

HUVECs,Visfatin,Heat shock protein 27 phosphorylation

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