MicroRNA-135a-3p is downregulated and serves as a tumour suppressor in ovarian cancer by targeting CCR2.

Shufeng Duan,Xuecai Dong,Jing Hai,Jinghong Jiang,Wenxiang Wang,Jing Yang,Wei Zhang,Caixia Chen

Biomedicine & Pharmacotherapy（2018）

引用 36|浏览9

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摘要

•MiR-135a-3p is down-regulated in ovarian carcinoma.•MiR-135a-3p inhibits ovarian cancer cell growth and aggressiveness.•CCR2 is the directly target gene of miR-135a-3p.•Over-expression of CCR2 reverses the inhibitory effect of miR-135a-3p.

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关键词

Ovarian cancer,miR-135a-3p,CCR2,Migration,Invasion

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