Treg Cells: A LAGging Hand Holds the Double-Edged Sword of the IL-23 Axis
Immunity（2018）
摘要
Intestinal Treg cells suppress colitis; yet the mechanisms behind the intricate pathways involved in this process remain largely unknown. In this issue of Immunity, Bauché et al. (2018) show that Treg cells engage MHCII on CX3CR1+ macrophages via LAG3. This indirectly reduces IL-22 mediated colonic inflammation.
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