Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP Γ-8

Suchitra Ravula,Brad M. Savall,Nyantsz Wu,Brian Lord,Kevin Coe, Kai Wang,Mark Seierstad,Devin M. Swanson,Jeannie Ziff,Minh Nguyen,Perry Leung, Ray Rynberg,David La,Daniel J. Pippel,Tatiana Koudriakova,Timothy W. Lovenberg,Nicholas Carruthers,Michael P. Maher,Michael K. Ameriks

ACS Medicinal Chemistry Letters（2018）

引用 13|浏览36

关键词

AMPA,alpha-amino-3-hydroxy-5-methy-4-isoxazolepropionic acid,AMPA,TARP gamma-8,transmembrane AMPA receptor regulatory protein,auxiliary subunit,glutamate,hippocampus,epilepsy,glutathione,autoradiography

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