Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity.
CHEMICAL COMMUNICATIONS(2018)
摘要
We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.
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关键词
gene-silencing
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