Targeted Temperature Management with Total Liquid Ventilation after Ischemic Spinal Cord Injury.

Background. Ischemic spinal cord injury is a devastating condition after aortic surgery. We determined whether ultrafast and short whole-body hypothermia provided by total liquid ventilation (TLV) attenuated lower limb paralysis after aortic cross-clamping with a targeted temperature management at 33 degrees C versus 36 degrees C. Methods. Anesthetized rabbits were submitted to infrarenal aortic cross-clamping during 15 min. A control group (n = 7) was maintained at normothermia (38 degrees C to 38.5 degrees C) with conventional mechanical ventilation. In TLV groups, TLV was started after reperfusion and maintained during 30 min with a target temperature at either 33 degrees C or 36 degrees C (TLV-33 degrees C and TLV-36 degrees C, respectively; n = 7 in each condition). After TLV, animals were resumed to conventional ventilation. Hypothermia was maintained during 120 min, before rewarming and awakening. Hind limb motor function was assessed with modified Tarlov score at day 2 and infarct size in the spinal cord was determined using triphenyltetrazolium chloride staining. Results. Target temperature was achieved within 20 minutes in the two TLV groups. At day 2, the modified Tarlov score was significantly lower in the control group, as compared with TLV-33 degrees C and TLV-36 degrees C groups (0.0 +/- 0.0 versus 3.1 +/- 0.7 and 2.6 +/- 0.6, respectively). The infarct size of the spinal cord was also significantly higher in the control group compared with TLV-33 degrees C and TLV-36 degrees C groups (75% +/- 10% versus 32% +/- 7% and 28% +/- 10%, respectively). Neither motor function nor infarct size differed significantly between TLV-33 degrees C and TLV-36 degrees C groups. Conclusions. Ultrafast hypothermic TLV attenuates spinal cord injury when applied after ischemic insult. Neurological outcome was similar with targeted temperature management at either 33 degrees C or 36 degrees C. (C) 2018 by The Society of Thoracic Surgeons