Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents.

Trinayan Kashyap,Christian Argueta,Thaddeus Unger,Boris Klebanov, Sophia Debler,William Senapedis,Marsha L Crochiere,Margaret S Lee,Michael Kauffman,Sharon Shacham,Yosef Landesman

Oncotarget（2018）

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摘要

Cancer cells treated with selinexor ± DDAs were analyzed using reverse phase protein arrays, immunoblots, quantitative PCR and immunofluorescence. Mice bearing MDA-MB-231 tumors were treated with subtherapeutic doses of selinexor, cisplatin, docetaxel and selinexor in combination with either cisplatin or docetaxel. Tumor growth was evaluated for 25 days.

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关键词

DNA damage repair,chemotherapy,nuclear export,selinexor

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