Early manifestation of depressive-like behavior in transgenic mice that express dementia with Lewy body-linked mutant β-synuclein.
Neuropsychopharmacology reports(2018)
摘要
Importantly, these non-motor behaviors were manifested before the onset of motor dysfunction, suggesting that P123H βS Tg mice could be a valid model for investigating the early phase of Lewy body disease.
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关键词
Lewy body diseases,behavior analysis,nonmotor symptoms,transgenic mice,β-synuclein
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