Targeting macrophages for cancer therapy disrupts bone homeostasis and impairs bone marrow erythropoiesis in mice bearing Lewis lung carcinoma tumors

Weiqiang Jing,Li Zhang,Fei Qin,XiuXiu Li,Xing Guo,Yue Li,Chunhong Qiu,Yunxue Zhao

Cellular Immunology（2018）

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摘要

•Depletion of CD169+ macrophages inhibits LLC tumor growth in mice.•Depletion of CD169+ macrophages leads to bone loss in LLC tumor-bearing mice.•Depletion of CD169+ macrophages impairs bone marrow erythropoiesis in LLC tumor-bearing mice.

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关键词

DT,DTR,WT,LLC,TAMs,BM,BMDMs,BMD,HSCs

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